期刊
PEPTIDES
卷 35, 期 2, 页码 160-165出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2012.03.031
关键词
Ghrelin; Tail suspension test; Olfactory bulbectomy; Hyperactivity; Antidepressant
资金
- CONICET (Consejo Nacional de Investigacion Cientifica y Tecnica)
- SECyT-UNC (Secretaria de Ciencia y Tecnica de la Universidad Nacional de Cordoba)
- Swedish Research Council (VR, Medicine)
This study aims to examine the antidepressant-like action of Ghrelin (Ghr), a hormone synthesized predominantly by gastrointestinal endocrine cells and released during periods of negative energy balance, in two behavioral models: tail suspension test (TST), a predictive model of antidepressant activity, and the olfactory bulbectomy (OB), an established animal model of depression. The reduction in the immobility time in the TST was the parameter used to assess antidepressant-like effect of Ghr. The depressive-like behavior in olfactory bulbectomized mice was inferred through the increase in the immobility time in the TST and the hyperlocomotor activity in the open-field test. Ghr produced antidepressant-like effect in TST (0.3 nmol/mu l, i.c.v.), and reversed OB-induced depressive-like behavior. In conclusion, these results provide clear evidence that an acute administration of ghrelin produce antidepressant-like effect in the TST and OB. (c) 2012 Elsevier Inc. All rights reserved.
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