4.4 Article

Circulating kisspeptin levels exhibit sexual dimorphism in adults, are increased in obese prepubertal girls and do not suffer modifications in girls with idiopathic central precocious puberty

期刊

PEPTIDES
卷 32, 期 9, 页码 1781-1786

出版社

ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2011.07.016

关键词

Kisspeptin; Leptin; Obesity; Central precocious puberty

资金

  1. Instituto de Salud Carlos III: Fondo de Investigacion Sanitaria [PI08053]
  2. CIBERobn [CB03-06]
  3. Fundacion Conchita Rabago

向作者/读者索取更多资源

The system KISS1-KISS1R is one of the main regulators of the hypothalamic-pituitary-gonadal axis and constitutes a link between metabolism and reproduction through its interaction with leptin. The aim of this study was to clarify the possible utility of kisspeptin as a pubertal marker and/or the possible influence of nutritional status in kisspeptin levels. To this end, we have studied kisspeptin plasma levels throughout sexual development and in prepubertal obese girls and girls affected by idiopathic central precocious puberty (CPP). Plasma kisspeptin concentrations were analyzed by RIA. An increase in kisspeptin levels was observed in adult females compared to healthy prepubertal and pubertal girls (p < 0.001) and to adult males (p < 0.001). Additionally, kisspeptin was increased in prepubertal obese girls compared to healthy prepubertal girls (p < 0.01) and girls with idiopathic CPP (p < 0.05). As revealed by the regression analysis, in prepubertal healthy and obese girls and girls with idiopathic CCP, the parameters that influenced kisspeptin levels were BMI (R-2 = 0.10, p < 0.05) and leptin levels (R-2 = 0.14, p < 0.01). In conclusion, kisspeptin levels do not seem to be a good pubertal marker. The results obtained in prepubertal and idiopathic CCP girls point to a relationship between leptin, BMI and kisspeptin at least in this group, and suggest a possible role for adipose tissue in the modulation kisspeptin synthesis. (C) 2011 Elsevier Inc. All rights reserved.

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