期刊
PEPTIDES
卷 29, 期 8, 页码 1305-1311出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2008.03.010
关键词
cyclic dipeptides; cancer cells; MCF-7; HT-29; HeLa
Six selected diketopiperazines, cyclo(Gly-Val), cyclo(Gly-D-Val), cyclo(Gly-Leu), cyclo(Gly-Ile), cyclo(Phe-Cys) and cyclo(Tyr-Cys), were synthesized via various synthetic routes. Their potential to inhibit cancer cell growth in HT-29, HeLa and MCF-7 cells was determined. Cyclo(Tyr-Cys) caused the greatest inhibition in cervical carcinoma cells with near equivalent activity against HT-29 and MCF-7 cells. The other cyclic dipeptides tested were effective in the inhibition of colon, cervical and breast carcinoma cells, respectively, but the percentage inhibition was lower than for cyclo(Tyr-Cys). (c) 2008 Elsevier Inc. All rights reserved.
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