期刊
TRIALS
卷 16, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s13063-015-0734-x
关键词
chemotherapy-induced nausea and vomiting; acupuncture; matching acupoint; randomized controlled trial
资金
- National Basic Research Program of China [2014CB543201]
- National Natural Science Foundation of China (NSFC) [81330088, 81403457]
Background: Many patients experience nausea and vomiting during chemotherapy treatment. Evidence demonstrates that electroacupuncture is beneficial for controlling chemotherapy-induced nausea and vomiting (CINV). However, the acupoint or matching acupoint with the best efficacy for controlling CINV still remains unidentified. Methods/Design: This study consists of a randomized controlled trial (RCT) with four parallel arms: a control group and three electroacupuncture groups (one with Neiguan (PC6), one with Zhongwan (CV12), and one with both PC6 and CV12). The control group received standard antiemetic only, while the other three groups received electroacupuncture stimulation with different acupoints besides the standard antiemetic. The intervention is done once daily from the first day (day 1) to the fourth day (day 4) during chemotherapy treatment. The primary outcome measures include frequency of nausea, vomiting and retching. The secondary outcome measures are the grade of constipation and diarrhea, electrogastrogram, assessment of quality of life, assessment of anxiety and depression, and other adverse effects during the chemotherapy. Assessments are scheduled from one day pre-chemotherapy (day 0) to the fifth day of chemotherapy (day 5). Follow-ups are done from day 6 to day 21. Discussion: The aim of this study is to evaluate the efficacy and safety of electro-acupuncture with different acupoints in the management of CINV.
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