期刊
TRENDS IN PHARMACOLOGICAL SCIENCES
卷 36, 期 1, 页码 22-31出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2014.11.001
关键词
G protein-coupled receptor; sequence alignments; mutational effects; ligand binding; structural motifs
资金
- Lundbeck Foundation - Carlsberg Foundation
- NIH [U54 GM094618, P01 DA035764]
- TIPharma
- COST Action CM1207 (GLISTEN)
- Lundbeck Foundation [R77-2010-6854] Funding Source: researchfish
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [U54GM094618] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [P01DA035764] Funding Source: NIH RePORTER
Generic residue numbers facilitate comparisons of, for example, mutational effects, ligand interactions, and structural motifs. The numbering scheme by Ballesteros and Weinstein for residues within the class A GPCRs (G protein-coupled receptors) has more than 1100 citations, and the recent crystal structures for classes B, C, and F now call for a community consensus in residue numbering within and across these classes. Furthermore, the structural era has uncovered helix bulges and constrictions that offset the generic residue numbers. The use of generic residue numbers depends on convenient access by pharmacologists, chemists, and structural biologists. We review the generic residue numbering schemes for each GPCR class, as well as a complementary structure-based scheme, and provide illustrative examples and GPCR database (GPCRDB) web tools to number any receptor sequence or structure.
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