期刊
TRENDS IN PHARMACOLOGICAL SCIENCES
卷 36, 期 1, 页码 15-21出版社
CELL PRESS
DOI: 10.1016/j.tips.2014.10.005
关键词
lipoidal bilayer diffusion; drug transporters; systems pharmacology; physiologically based pharmacokinetic modelling
资金
- Biotechnology and Biological Sciences Research Council [BB/M017702/1]
- BBSRC [BB/M017702/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/M017702/1] Funding Source: researchfish
For drug transport across (i.e., through) an intact biological membrane, two main routes are possible: drugs may cross (i) through the phospholipid bilayer portion of the membrane, and/or (ii) via proteinaceous pores or transporters. Perhaps surprisingly, there is in fact no direct scientific evidence that the first of these takes place at any significant rate because, in the experiments performed to date, it has neither been varied as an independent variable nor measured directly as a dependent variable. Using a standard hypothetico-deductive framework, I assess the intellectual and observable consequences of assuming that, for drugs, phospholipid bilayer diffusion is negligible - 'PBIN' - (i.e., may be neglected, relative to transporter-mediated transmembrane fluxes). Predictions and postdictions of the PBIN hypothesis are not refuted by available experimental evidence.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据