期刊
TRENDS IN PHARMACOLOGICAL SCIENCES
卷 36, 期 9, 页码 605-616出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2015.06.004
关键词
myocardial infarction; reperfusion injury; coronary microcirculation; novel therapeutics
Despite the large number of novel therapies under basic scientific investigation, the translation of cardioprotective strategies targeting repel-fusion injury to improve patient outcomes following percutaneous coronary intervention (PCI) for myocardial infarction (MI) has been disappointing. The varying susceptibility of an individual to reperfusion injury, as well as the narrow window of opportunity in which to intervene, adds significant complexity. Here, we discuss the unmet need and challenges of translating cardioprotective strategies into clinical practice, review the pathophysiology of microvascular dysfunction and lethal reperfusion as they relate to promising novel therapeutics, and evaluate recent and ongoing clinical trials in the field.
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