期刊
TRENDS IN NEUROSCIENCES
卷 38, 期 2, 页码 96-107出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2014.12.003
关键词
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资金
- National Institutes of Mental Health [MH096764]
- Howard Hughes Medical Institute
- Burroughs Wellcome Fund
- Department of Psychiatry and Behavioral Sciences, Emory School of Medicine
- EMBO long-term fellowship
Gene expression and regulation is an important sculptor of the behavior of organisms. Epigenetic mechanisms regulate gene expression not by altering the genetic alphabet but rather by the addition of chemical modifications to proteins associated with the alphabet or of methyl marks to the alphabet itself. Being dynamic, epigenetic mechanisms of gene regulation serve as an important bridge between environmental stimuli and genotype. In this review, we outline epigenetic mechanisms by which gene expression is regulated in animals and humans. Using fear learning as a framework, we then delineate how such mechanisms underlie learning and stress responsiveness. Finally, we discuss how epigenetic mechanisms might inform us about the transgenerational inheritance of behavioral traits that are being increasingly reported.
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