期刊
TRENDS IN NEUROSCIENCES
卷 38, 期 8, 页码 462-465出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2015.06.006
关键词
endocannabinoid signaling; stress-induced anxiety; protein tyrosine phosphatase PTP1B; anxiolytic therapy; trodusquemine/MSI-1436; glutamate receptor
资金
- NCI NIH HHS [R37 CA053840, R01 CA053840, CA45508, CA53840, P30 CA045508] Funding Source: Medline
- NIGMS NIH HHS [GM55989, R01 GM055989] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [P30CA045508, R37CA053840, R01CA053840] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM055989] Funding Source: NIH RePORTER
Chronic stress can lead to the development of anxiety and mood disorders. Thus, novel therapies for preventing adverse effects of stress are vitally important. Recently, the protein tyrosine phosphatase PTP1B was identified as a novel regulator of stress-induced anxiety. This opens up exciting opportunities to exploit PTP1B inhibitors as anxiolytics.
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