期刊
TRENDS IN MOLECULAR MEDICINE
卷 21, 期 9, 页码 533-542出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2015.07.004
关键词
extracellular vesicle; exosome; microRNA; COPD; lung cancer; mesenchymal stem cell
资金
- Foundation for Promotion of Cancer Research (Japan)
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science
- Program for the Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation (NiBio)
Increasing attention is being paid to the role of extracellular vesicles (EVs) in various lung diseases. EVs are released by a variety of cells, including respiratory cells and immune cells, and they encapsulate various molecules, such as proteins and microRNAs, as modulators of intercellular communication. Cancer cell-derived EVs play crucial roles in promoting tumor progression and modifying their microenvironment. By contrast, noncancerous cell-derived EVs demonstrate protective functions against injury, such as tissue recovery and repair, to maintain physiological homeostasis. Airway cells in contact with harmful substances may alter their EV composition and modify the balanced reciprocal interactions with surrounding mesenchymal cells. We summarize the novel findings of EV function in various lung diseases, primarily chronic obstructive pulmonary disease (COPD) and lung cancer.
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