期刊
TRENDS IN MOLECULAR MEDICINE
卷 21, 期 9, 页码 543-548出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2015.07.005
关键词
neurorestorative therapy; stroke recovery; miRNAs; exosomes
资金
- National Institutes of Health (NIH) [R01 NS 088656, R01 NS079612]
Endogenous brain repair after stroke involves a set of highly interactive processes, such as angiogenesis, neurogenesis, oligodendrogenesis, synaptogenesis, and axonal outgrowth, which together orchestrate neurological recovery. During the past several years, there have been advances in our understanding of miRNAs and histone deacetylases (HDACs) in brain repair processes after stroke. Emerging data indicate the important role of exosomes for intercellular communication in promoting coupled brain remodeling processes. These advances will likely have a major impact on the development of restorative therapies for ischemic brain repair, consequently leading to improvement of neurological function. In this review, we provide an update on our current understanding of cellular and molecular mechanisms of miRNAs, exosomes, and HDACs in brain restorative processes after stroke.
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