期刊
TRENDS IN MOLECULAR MEDICINE
卷 21, 期 7, 页码 408-416出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2015.04.002
关键词
primary immunodeficiencies; T lymphocytes; autoimmunity; innate immunity; inflammation
Primary immunodeficiencies (PIDs) constitute a large group of rare disorders that affect the function of the immune system. These deficiencies are usually associated with inability to prevent infections but can also result in allergy, inflammation, autoimmunity, and cancer. The recent characterization of many different monogenic defects has shed light on a range of non-redundant differentiation, effector, and regulatory functions of immune cells. The present review focuses on PIDs that affect adaptive immunity in general and T lymphocytes in particular. The analysis of PIDs is now opening up new pathways towards targeted therapies.
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