期刊
TRENDS IN MOLECULAR MEDICINE
卷 21, 期 10, 页码 595-608出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2015.08.002
关键词
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资金
- FCT [SFRH/BD/98054/2013, SFRH/BPD/68787/2010]
- Portuguese Foundation for Science and Technology
- FEDER funds through the Operational Programme for Competitiveness Factors-COMPETE
- national funds through the FCT [PEst-C/SAU/LA0003/2013]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/98054/2013] Funding Source: FCT
Extracellular vesicles (EVs) are nanosized particles (100-1000 nm) enclosed by a phospholipid bilayer that have been described as important mediators of intercellular communication. The role of EVs in oncobiology has been extensively studied, including their contribution to the horizontal transfer of drug resistance from drug-resistant to drug-sensitive cancer cells. This review focuses on the EVs cargo responsible for this intercellular transfer of drug resistance; namely, drug-efflux pumps, miRNAs, long noncoding RNAs (IncRNAs), and other mediators. Additionally, the known molecular mechanisms and features of this transfer are discussed. This is an emerging area of research and we highlight topics that need to be further studied to fully understand and counteract the intercellular transfer of drug resistance mediated by EVs.
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