期刊
TRENDS IN MOLECULAR MEDICINE
卷 21, 期 3, 页码 184-192出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2014.12.008
关键词
atherosclerosis; extracellular ATP; ecto-nucleotidases; adenosine; P1 receptors; P2 receptors
资金
- Commission of European Union
Cell surface expression of specific receptors and ectonucleotidases makes extracellular nucleotides such as ATP, ADP, UTP, and adenosine suitable as signaling molecules for physiological and pathological events, including tissue stress and damage. Recent data have revealed the participation of purinergic signaling in atherosclerosis, depicting a scenario in which, in addition to some exceptions reflecting dual effects of individual receptor subtypes, adenosine and most P1 receptors, as well as ecto-nucleotidases, show a protective, antiatherosclerotic function. By contrast, P2 receptors promote atherosclerosis. In consideration of these findings, modulation of purinergic signaling would represent an innovative and valuable tool to counteract atherosclerosis. We summarize recent developments on the participation of the purinergic network in atheroma formation and evolution.
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