期刊
TRENDS IN MICROBIOLOGY
卷 23, 期 1, 页码 22-34出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2014.10.003
关键词
bacterial microcompartments; carboxysomes; metabolosomes; synthetic biology; bacterial organelles
资金
- US Department of Energy, Office of Basic Energy Sciences [DE-AC02 05CH11231]
- National Science Foundation [MCB1160614, EF1105892]
Bacterial microcompartments (BMCs) are protein-bound organelles predicted to be present across 23 bacterial phyla. BMCs facilitate carbon fixation as well as the aerobic and anaerobic catabolism of a variety of organic compounds. These functions have been linked to ecological nutrient cycling, symbiosis, pathogenesis, and cardiovascular disease. Within bacterial cells, BMCs are metabolic modules that can be further dissociated into their constituent structural and functional protein domains. Viewing BMCs as genetic, structural, functional, and evolutionary modules provides a framework for understanding both BMC-mediated metabolism and for adapting their architectures for applications in synthetic biology.
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