期刊
TRENDS IN MICROBIOLOGY
卷 23, 期 3, 页码 172-180出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2014.12.004
关键词
Chiroptera; emerging zoonotic pathogens; immunopathology; immunological tolerance; reactive oxygen species
资金
- Princeton University
- National Science Foundation
The ongoing West African Ebola epidemic highlights a recurring trend in the zoonotic emergence of virulent pathogens likely to come from bat reservoirs that has caused epidemiologists to ask 'Are bats special reservoirs for emerging zoonotic pathogens?' We collate evidence from the past decade to delineate mitochondrial mechanisms of bat physiology that have evolved to mitigate oxidative stress incurred during metabolically costly activities such as flight. We further describe how such mechanisms might have generated pleiotropic effects responsible for tumor mitigation and pathogen control in bat hosts. These synergisms may enable 'special' tolerance of intracellular pathogens in bat hosts; paradoxically, this may leave them more susceptible to immunopathological morbidity when attempting to clear extracellular infections such as 'white-nose syndrome' (WNS).
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