期刊
TRENDS IN MICROBIOLOGY
卷 23, 期 2, 页码 110-119出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2014.10.007
关键词
nucleoside antibiotics; biosynthesis; regulation; genetic engineering
资金
- Ministry of Science and Technology of China [2013CB734001, 2015CB150602]
- National Natural Science Foundation of China [31270110, 31030003]
The alarming rise in antibiotic-resistant pathogens has coincided with a decline in the supply of new antibiotics. It is therefore of great importance to find and create new antibiotics. Nucleoside antibiotics are a large family of natural products with diverse biological functions. Their biosynthesis is a complex process through multistep enzymatic reactions and is subject to hierarchical regulation. Genetic and biochemical studies of the biosynthetic machinery have provided the basis for pathway engineering and combinatorial biosynthesis to create new or hybrid nucleoside antibiotics. Dissection of regulatory mechanisms is leading to strategies to increase the titer of bioactive nucleoside antibiotics.
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