期刊
TRENDS IN MICROBIOLOGY
卷 23, 期 5, 页码 301-310出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2015.02.012
关键词
bacterial conjugation; DNA transport; substrate secretion; Type IV secretion system; T4SS; structural biology
资金
- Wellcome Trust [098302]
Conjugation, the process by which plasmid DNA is transferred from one bacterium to another, is mediated by type IV secretion systems (T4SSs). T4SSs are versatile systems that can transport not only DNA, but also toxins and effector proteins. Conjugative T4SSs comprise 12 proteins named VirB1-11 and VirD4 that assemble into a large membrane-spanning exporting machine. Before being transported, the DNA substrate is first processed on the cytoplasmic side by a complex called the relaxosome. The substrate is then targeted to the T4SS for export into a recipient cell. In this review, we describe the recent progress made in the structural biology of both the relaxosome and the T4SS.
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