期刊
PEDIATRICS
卷 125, 期 2, 页码 E438-E441出版社
AMER ACAD PEDIATRICS
DOI: 10.1542/peds.2009-1901
关键词
rotavirus; acute gastroenteritis; RotaTeq; rotavirus vaccine; WC3; sibling transmission; horizontal transmission; shedding; reassortant; New Vaccine Surveillance Network; NVSN
类别
Although rotavirus vaccines are known to be shed in stools, transmission of vaccine-derived virus to unvaccinated contacts resulting in symptomatic rotavirus gastroenteritis has not been reported to our knowledge. We document here the occurrence of vaccine-derived rotavirus (RotaTeq [Merck and Co, Whitehouse Station, NJ]) transmission from a vaccinated infant to an older, unvaccinated sibling, resulting in symptomatic rotavirus gastroenteritis that required emergency department care. Results of our investigation suggest that reassortment between vaccine component strains of genotypes P7[5] G1 and P1A[8] G6 occurred during replication either in the vaccinated infant or in the older sibling, raising the possibility that this reassortment may have increased the virulence of the vaccine-derived virus. Both children remain healthy 11 months after this event and are without underlying medical conditions. Pediatrics 2010;125:e438-e441
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据