期刊
TRENDS IN IMMUNOLOGY
卷 36, 期 12, 页码 753-755出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2015.10.004
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资金
- Bill and Melinda Gates Foundation
- RAPIDD program of the Science and Technology Directorate, Department of Homeland Security
- Fogarty International Center, National Institutes of Health
Individual immunity is a powerful force affecting host health and pathogen evolution. Importantly, the effects of individual immunity also scale up to affect pathogen transmission dynamics and the success of vaccination campaigns for entire host populations. Population-scale immunity is often termed 'herd immunity'. Here we outline how individual immunity maps to population outcomes and discuss implications for control of infectious diseases. Particular immunological characteristics may be more or less likely to result in a population level signature of herd immunity; we detail this and also discuss other population-level outcomes that might emerge from individual-level immunity.
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