期刊
PEDIATRICS
卷 126, 期 4, 页码 E828-E835出版社
AMER ACAD PEDIATRICS
DOI: 10.1542/peds.2009-3188
关键词
viral; infection; cerebrospinal fluid; brain
类别
资金
- Jerring Foundation
- Swedish Insurance Association
- Frimurarna Barnhuset Foundation
- Barnavard Foundation
- Magnus Bergvalls Foundation
OBJECTIVES: The aims of this study were to investigate the long-term outcomes of childhood encephalitis and to examine possible prognostic factors. METHODS: Of 93 children who were treated for acute encephalitis in 2000-2004, 71 were eligible for follow-up evaluations. A structured interview, using 2 questionnaires, was conducted with the parents. Fifteen of the children with the most-severe symptoms at the time of discharge also underwent electroencephalographic recording and tests of reaction times and working memory. RESULTS: Persisting symptoms were reported by 54% of children. The predominant symptoms were personality changes and cognitive problems. Children who made a complete recovery did so within 6 to 12 months. The only significant risk factor for sequelae was disease severity leading to admission to the ICU. The risk of subsequent epilepsy was increased for children with seizures at presentation. Most follow-up electroencephalograms showed improvement, but results had not normalized for 9 of 15 children. Children with encephalitis had slower reaction times, compared with control subjects, but no difference in working memory could be seen. CONCLUSION: Persisting symptoms after childhood encephalitis were present for a substantial number of children. Seizures increased the risk of subsequent epilepsy; the only other prognostic marker was admission to the ICU. Even children who were considered fully recovered at discharge reported persisting symptoms at follow-up evaluations. Children who made a full recovery did so within 6 to 12 months, which suggests that all children with encephalitis should be monitored for 1 year after the acute illness. Pediatrics 2010;126:e828-e835
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据