期刊
TRENDS IN IMMUNOLOGY
卷 36, 期 12, 页码 763-777出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2015.10.003
关键词
-
类别
资金
- Swiss National Science Foundation [PP00P3-150751]
- Swiss Cancer League grant [KFS-3375-02-2014]
- University of Zurich
- Swiss National Science Foundation (SNF) [PP00P3_150751] Funding Source: Swiss National Science Foundation (SNF)
Interleukin-2 (IL-2) exerts crucial functions during immune homeostasis via its effects on regulatory T (Treg) cells, and the optimizing and fine-tuning of effector lymphocyte responses. Thus, somewhat paradoxically, low doses of recombinant IL-2 have been used for Treg cell-based immunosuppressive strategies against immune pathologies, while high-dose IL-2 has shown some success in stimulating anti-tumor immune responses. Recent studies of the functional, biophysical and structural characteristics of IL-2 have led to the generation of IL-2 formulations, including IL-2/mAb complexes and IL-2 variants (muteins) that selectively enhance IL-2's immune stimulatory versus inhibitory properties. Here, we review these findings, placing new mechanistic insights into improved next-generation IL-2 formulations within the broader context of IL-2 biology. We conclude by integrating these findings into a framework for understanding IL-2-mediated selective immune modulation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据