期刊
TRENDS IN IMMUNOLOGY
卷 36, 期 7, 页码 401-409出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2015.05.006
关键词
IRE1; RIG-I; innate immunity; mucosal immunity; inflammation; intestine
类别
资金
- NIH [DK048106, DK084424]
- CCFA [CDA330011, K01 DK102828]
- NIH P30 Harvard Digestive Diseases Center [DK034854]
Recent studies have linked the ER stress sensor IRE1 alpha with the RIG-I pathway, which triggers an inflammatory response upon detection of viral RNAs. In response to ER dysfunction, IRE1 alpha cleaves mRNA into single-strand fragments that lack markers of self, which activate RIG-I. Certain microbial products from mucosal pathogens activate this pathway by binding IRE1 alpha directly, and the discovery that IRE1 is amplified at mucosal surfaces by gene duplication suggests an important role for IRE1 in mucosal immunity. Here, we review evidence in support of this hypothesis, and propose a model wherein IRE1 surveys the integrity of the ER, acting as a guard receptor and a pattern recognition receptor, capable both of sensing cellular stress caused by microbial infection and of responding to pathogens directly.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据