4.7 Article

Biological and Environmental Predictors of Behavioral Sequelae in Children Born Preterm

期刊

PEDIATRICS
卷 125, 期 1, 页码 E83-E89

出版社

AMER ACAD PEDIATRICS
DOI: 10.1542/peds.2009-0634

关键词

prematurity; behavior; predictors

资金

  1. National Institutes of Health [HL046925]
  2. NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL046925] Funding Source: NIH RePORTER

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OBJECTIVE: By using behavioral outcome measures of children who were born preterm, we evaluated differences between children who were born at term and children who were born at extremely low (ELBW; <1000 g) and very low birth weights (VLBW; 1000-1499 g) and assessed the relationship of birth weight, socioeconomic status, and cognitive ability to behavioral outcome. METHODS: We studied a total of 104 children (aged 7-16 years). Of these, 49 had a preterm birth (31 of ELBW and 18 of VLBW). The remaining 55 were healthy control subjects. Children were administered tests of cognitive ability. Parents and teachers completed behavioral assessments. Multivariate analyses of covariance assessed differences between children who were born at term and those who were born of ELBW and of VLBW on behavioral measures. Hierarchical linear regressions were used to assess relationships among biological (birth weight), environmental (socioeconomic status), intellectual, and behavioral variables. RESULTS: Children who were born at term had fewer parent reports of hyperactivity/inattention and depression/anxiety symptoms than children of ELBW and VLBW. Teacher ratings were not significant between groups. Birth weight was consistently the strongest predictor of parent ratings of behavioral outcome, and intelligence level did not seem to mediate this relationship. CONCLUSIONS: Negative behavioral sequelae of preterm birth remain significant in middle childhood and adolescence, although the contribution of multiple factors to neurobehavioral outcome is complex. Research to assess these relationships, integrated with anatomic and functional neuroimaging, is needed to advance knowledge and improve outcomes for children who are born preterm. Pediatrics 2010; 125: e83-e89

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