期刊
TRENDS IN IMMUNOLOGY
卷 36, 期 7, 页码 428-435出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2015.05.003
关键词
immune memory; immune homeostasis; naive T cells; mucosal immunity; peripheral blood
类别
资金
- National Institutes of Health (NIH) [AI100119, AI106697, HL116136]
- NIH F31 pre-doctoral fellowship [AG047003]
- BD Bioscience research grant
Intensified efforts to promote protective T cell-based immunity in vaccines and immunotherapies have created a compelling need to expand our understanding of human T cell function and maintenance beyond its characterization in peripheral blood. Mouse studies of T cell immunity show that, in response to infection, T cells migrate to diverse sites and persist as tissue-resident memory T cells (TRM), which mediate rapid in situ protection on antigen recall. Here we discuss new approaches to probe human T cell immunity, including novel sampling, that indicate a broad distribution and high frequency of human TRM in multiple sites. These newer findings further implicate anatomic compartmentalization as a generalized mechanism for long-term maintenance of human T cells throughout life.
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