期刊
TRENDS IN GENETICS
卷 31, 期 6, 页码 329-335出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2015.02.002
关键词
IncRNAs; embryo; development; organ; cell lineage
资金
- Max Planck Society
- DFG (German Research Foundation) Excellence Cluster Cardio-Pulmonary System [Exc147-2]
A large proportion of the cellular transcriptome of higher vertebrates consists of non-protein coding transcripts, among them the long noncoding RNAs (IncRNAs). Although IncRNAs are functionally extremely divergent, many ncRNAs have been shown to interact with chromatin modifying complexes and/or with transcriptional regulators. Via such interactions, many IncRNAs are involved in controlling the activity and expression level of target genes, including important regulators of embryonic processes, and thereby fine-tune gene regulatory networks controlling cell fate, lineage balance, and organogenesis. Intriguingly, an increase in organ complexity during evolution parallels a rise in IncRNA abundance. The current data suggest that IncRNAs support the generation of cell diversity and organ complexity during embryogenesis, and thereby have promoted the evolution of more complex organisms.
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