期刊
TRENDS IN GENETICS
卷 31, 期 12, 页码 696-708出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2015.10.004
关键词
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资金
- British Society for Haematology (BSH)
- Roslin Foundation
- Chancellor's Fellowship at University of Edinburgh
- Biotechnology and Biological Sciences Research Council (BBSRC)
- UK Medical Research Council (MRC)
- European Research Council (ERC) [249956]
- BBSRC [BBS/E/D/20221657] Funding Source: UKRI
- MRC [MC_PC_U127527202] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/D/20221657] Funding Source: researchfish
- Medical Research Council [MC_PC_U127527202] Funding Source: researchfish
Regulatory elements (enhancers) that are remote from promoters play a critical role in the spatial, temporal, and physiological control of gene expression. Studies on specific loci, together with genome-wide approaches, suggest that there may be many common mechanisms involved in enhancer-promoter communication. Here, we discuss the multiprotein complexes that are recruited to enhancers and the hierarchy of events taking place between regulatory elements and promoters.
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