期刊
TRENDS IN GENETICS
卷 31, 期 7, 页码 353-356出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2015.03.009
关键词
mitochondrial epigenetics; mitoepigenetics; DNA methylation; DNA hydroxymethylation; mtDNMT1; mtDNA
Despite decades of research, mitochondrial epigenetics remains a controversial notion. Recent findings, however, indicate that dysfunctional mitochondrial DNA (mtDNA) methylation could underlie aging and disease. Unraveling such a level of regulation will be essential in the understanding of and in interfering with the role of mitochondria in many physiological and pathophysiological processes.
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