期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 26, 期 7, 页码 337-338出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2015.05.011
关键词
SGLT-2 inhibitors; glucagon; alpha-cell; glucose production; HNF4alpha
资金
- NIDDK NIH HHS [R01 DK092606] Funding Source: Medline
Recent studies raised the alarm that the inhibition of sodium-coupled glucose transporter type-2 in humans increases endogenous glucose production rates by an unclear mechanism. Surprisingly, a potential explanation may be linked directly to the alpha-cell. Is this a mechanistic spoiler or an added benefit?
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