期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 26, 期 6, 页码 322-331出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2015.03.008
关键词
brain tumors; radioresistance; iron signaling; drug delivery; hypoxia; nanoparticles
资金
- Ligue Nationale Contre le Cancer through an Equipe Labellisee grant
- INSERM
- Region Pays-de-la-Loire through the Nuclear Technology for Health project (NucSan)
- Canceropole Grand-Ouest including the Axe Vectorisation and Radiotherapies
- Reseau Gliome Grand Ouest (ReGGO)
Glioblastoma (GBM), the deadliest primary tumor of the central nervous system (CNS), is a clear illustration of the resistance of cancer cells to conventional therapies. Application of combinatorial strategies able to overcome pivotal factors of GBM resistance, particularly within the resection margins, represents an essential issue. This review focuses on the role of iron metabolism in GBM progression and resistance to therapy, and the impact of its pharmaceutical modulation on the disease. Iron, through its involvement in many biological processes, is a key factor in the control of cell behavior and cancer biology. Therefore, targeting cellular iron signaling or taking advantage of its dysregulation in cancer cells may lead to new opportunities for improving treatments and drug delivery in GBM.
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