期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 26, 期 2, 页码 75-83出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2014.11.003
关键词
poly(ADP-ribose) polymerase; NAD(+); AMP activated kinase; Sirtuin; hypoxia-inducible factor; nuclear respiratory factor
资金
- Bolyai
- Momentum fellowship of the Hungarian Academy of Sciences
- OTKA [K108308, K105872, TAMOP-4.2.2.A-11/1/KONV-2012-0025]
- Intramural Research Program of NIH/NIAAA
Mitochondria are essential in cellular stress responses. Mitochondrial output to environmental stress is a major factor in metabolic adaptation and is regulated by a complex network of energy and nutrient sensing proteins. Activation of poly(ADP-ribose) polymerases (PARPs) has been known to impair mitochondrial function; however, our view of PARP-mediated mitochondrial dysfunction and injury has only recently fundamentally evolved. In this review, we examine our current understanding of PARP-elicited mitochondria! damage, PARP-mediated signal transduction pathways, transcription factors that interact with PARPs and govern mitochondrial biogenesis, as well as mitochondrial diseases that are mediated by PARPs. With PARP activation emerging as a common underlying mechanism in numerous pathologies, a better understanding the role of various PARPs in mitochondrial regulation may help open new therapeutic avenues.
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