期刊
TRENDS IN COGNITIVE SCIENCES
卷 19, 期 10, 页码 616-628出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tics.2015.07.011
关键词
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资金
- European Research Council (ERG) Consolidator Grant: CAREGIVING [615539]
- ERG Advanced Grant: DYSTRUCTURE [295129]
- Spanish Research Project [PSI2013-42091-P]
- German Ministry of Education and Research (Bernstein Focus State Dependencies of Learning) [01GQ0971-5]
- S. McDonnell Foundation (Brain Network Recovery Group JSMF) [22002082]
- Max-Planck Society (Minerva Program)
- European Commission Seventh Framework Programme (FP7-ICT Human Brain Project grant) [60402]
- European Research Council (ERC) [615539] Funding Source: European Research Council (ERC)
- ICREA Funding Source: Custom
Slowness of thought is not necessarily a handicap but could be a signature of optimal brain function. Emerging evidence shows that neuroanatomical and dynamical constraints of the human brain shape its functionality in optimal ways, characterized by slowness during task-based cognition in the context of spontaneous resting-state activity. This activity can be described mechanistically by whole-brain computational modeling that relates directly to optimality in the context of theories arguing for metastability in the brain. We discuss the role for optimal processing of information in the context of cognitive, task-related activity, and propose that combining multi-modal neuroimaging and explicit whole-brain models focused on the timing of functional dynamics can help to uncover fundamental rules of brain function in health and disease.
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