期刊
TRENDS IN CELL BIOLOGY
卷 25, 期 9, 页码 556-566出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2015.06.003
关键词
collective migration; leader cells; guidance cues; mechanocoupling; signal integration; extracellular matrix
类别
资金
- Dutch Cancer Foundation [KWF 2008-4031]
- NWO-VICI [918.11.626]
- Cancer Genomics Cancer, The Netherlands
- NWO-VIDI [917.10.364]
- European Commission [302067]
Collective cell migration results from the establishment and maintenance of collective polarization, mechano-coupling, and cytoskeletal kinetics. The guidance of collective cell migration depends on a reciprocal process between cell-intrinsic multicellular organization with leader follower cell behavior and results in mechanosensory integration of extracellular guidance cues. Important guidance mechanisms include chemotaxis, haptotaxis, durotaxis, and strain-induced mechanosensing to move cell groups along interfaces and paths of least resistance. Additional guidance mechanisms steering cell groups during specialized conditions comprise electrotaxis and passive drift. To form higher-order cell and tissue structures during morphogenesis and cancer invasion, these guidance principles act in parallel and are integrated for collective adaptation to and shaping of varying tissue environments. We review mechanochemical and electrical inputs and multiparameter signal integration underlying collective guidance, decision making, and outcome.
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