期刊
PEDIATRIC RESEARCH
卷 76, 期 1, 页码 100-108出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/pr.2014.48
关键词
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类别
资金
- National Institutes of Health (NIH), Bethesda, MD (General Clinical Research Center) [M01 RR30, M01 RR32, M01 RR39, M01 RR70, M01 RR80, M01 RR633, M01 RR750, M01 RR997, M01 RR6022, M01 RR7122, M01 RR8084, M01 RR16587]
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- NIH [U01 HD36790, U10 HD21364, U10 HD21373, U10 HD21385, U10 HD21397, U10 HD21415, U10 HD27851, U10 HD27853, U10 HD27856, U10 HD27871, U10 HD27880, U10 HD27881, U10 HD27904, U10 HD34216, U10 HD40461, U10 HD40492, U10 HD40498, U10 HD40689, R01HD059142]
- US Centers for Disease Control and Prevention, Atlanta, GA [Y1-HD-5000-01]
BACKGROUND: The goal was to identify cytokines associated with necrotizing enterocolitis (NEC). Based on our earlier reports of decreased tissue expression of transforming growth factor (TGF)-beta, we hypothesized that infants with NEC also have low blood TGF-beta levels. We further hypothesized that because fetal inflammation increases the risk of NEC, infants who develop NEC have elevated blood cytokine levels in early neonatal period. METHODS: Data on 104 extremely-low-birth-weight infants with NEC and 893 without NEC from 17 centers were analyzed. Clinical information was correlated with blood cytokine levels on postnatal day 1 (D1), D3, D7, D14, and D21. RESULTS: Male gender, non-Caucasian/non-African American ethnicity, sepsis, lower blood TGF-beta and interleukin (IL)-2 levels, and higher IL-8 levels were associated with NEC. The NEC group had lower TGF-beta levels than controls since D1. The diagnosis of NEC was associated with elevated IL-1 beta, IL-6, IL-8, IL-10, monocyte chemoattractant protein-1/CC-motif ligand-2, macrophage inflammatory protein-1 beta/CC-motif ligand-3, and C-reactive protein. CONCLUSION: Clinical characteristics, such as gender and ethnicity, and low blood TGF-beta levels are associated with higher risk of NEC. Infants who developed NEC did not start with high blood levels of inflammatory cytokines, but these rose mainly after the onset of NEC.
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