期刊
TRENDS IN CELL BIOLOGY
卷 25, 期 1, 页码 21-28出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2014.08.006
关键词
kinetochore; spindle; checkpoint; aneuploidy; microtubule
类别
资金
- European Research Council (ERC-StG KINSIGN)
- Netherlands Organisation for Scientific Research (NWO) [Vici 865.12.004]
Error-free chromosome segregation relies on stable connections between kinetochores and spindle microtubules. The spindle assembly checkpoint (SAC) monitors such connections and relays their absence to the cell cycle machinery to delay cell division. The molecular network at kinetochores that is responsible for microtubule binding is integrated with the core components of the SAC signaling system. Molecular-mechanistic understanding of how the SAC is coupled to the kinetochore microtubule interface has advanced significantly in recent years. The latest insights not only provide a striking view of the dynamics and regulation of SAC signaling events at the outer kinetochore but also create a framework for understanding how that signaling may be terminated when kinetochores and microtubules connect.
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