期刊
TRENDS IN CELL BIOLOGY
卷 25, 期 4, 页码 198-213出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2014.11.006
关键词
tumor microenyironment; stroma; therapeutic resistance; chemotherapy; radiotherapy; immunotherapy
类别
资金
- National Institutes of Health [CA181355, CA148967]
- American Cancer Society [RSG-12-076-01-LIB]
- Breast Cancer Research Foundation
- Deutsche Forschungsgemeinschaft [KL 2491/1-1]
The tumor microenvironment (TME) not only plays a pivotal role during cancer progression and metastasis but also has profound effects on therapeutic efficacy. In the case of microenvironment-mediated resistance this can involve an intrinsic response, including the co-option of pre-existing structural elements and signaling networks, or an acquired response of the tumor stroma following the therapeutic insult. Alternatively, in other contexts, the TME has a multifaceted ability to enhance therapeutic efficacy. This review examines recent advances in our understanding of the contribution of the TME during cancer therapy and discusses key concepts that may be amenable to therapeutic intervention.
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