期刊
TRENDS IN CELL BIOLOGY
卷 25, 期 3, 页码 148-157出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2014.11.007
关键词
endothelial cells; angiogenesis; lung; liver; bone marrow organ morphogenesis; angiocrine signaling; vascular niche
类别
资金
- Max Planck Society
- University of Munster
- Deutsche Forschungsgemeinschaft (DFG) cluster of excellence 'Cells in Motion'
- European Research Council [AdG 339409 AngioBone]
Endothelial cells (ECs) form an extensive network of blood vessels that has numerous essential functions in the vertebrate body. In addition to their well-established role as a versatile transport network, blood vessels can induce organ formation or direct growth and differentiation processes by providing signals in a paracrine (angiocrine) fashion. Tissue repair also requires the local restoration of vasculature. ECs are emerging as important signaling centers that coordinate regeneration and help to prevent deregulated, disease-promoting processes. Vascular cells are also part of stem cell niches and have key roles in hematopoiesis, bone formation, and neurogenesis. Here, we review these newly identified roles of ECs in the regulation of organ morphogenesis, maintenance, and regeneration.
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