期刊
TRENDS IN CELL BIOLOGY
卷 25, 期 5, 页码 296-307出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2014.12.002
关键词
microtubule; gamma-tubulin complex; mitotic spindle; centrosome; spindle pole body
类别
资金
- Deutsche Forschungsgemeinschaft [Schi 295/4-2]
Organisms with closed or open mitosis have differentially evolved various gamma-tubulin complex (gamma-TuC) recruiting factors to organize diverse cellular microtubule (MT) arrays, including the mitotic spindle. gamma-TuC recruiting factors not only target the gamma-TuC to MT nucleation sites, but also regulate MT nucleation activity by generating the template for MT nucleation or promoting the MT nucleation activity of pre-existing gamma-tubulin ring complexes (gamma-TuRCs). Here we outline the current understanding of MT nucleator assembly and its regulation by gamma-tubulin small complex (gamma-TuSC) receptors. Moreover, we discuss the emergence of gamma-TuC recruiting factors through evolution with augmented complexity and diversity and propose a hypothesis to account for the evolution of these factors in cooperative spindle assembly.
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