期刊
PEDIATRIC RESEARCH
卷 74, 期 4, 页码 450-456出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/pr.2013.119
关键词
-
类别
资金
- Medical Research Council
- British Heart Foundation
- Arthritis Research UK
- National Osteoporosis Society
- International Osteoporosis Foundation
- Cohen Trust
- National Institute for Health Research Southampton Biomedical Research Centre
- University of Southampton
- University Hospital Southampton NHS Foundation Trust
- NIHR Musculoskeletal Biomedical Research Unit, University of Oxford
- European Union [289346]
- MRC [G0400491, MC_UU_12011/4, MC_UP_A620_1017] Funding Source: UKRI
- British Heart Foundation [RG/07/009/23120] Funding Source: researchfish
- Medical Research Council [G0400491, MC_UU_12011/1, MC_UP_A620_1014, MC_UP_A620_1017, U1475000001, MC_UU_12011/4, MC_U147585824] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0508-10082] Funding Source: researchfish
BACKGROUND: We investigated relationships between early growth and proximal femoral geometry at age 6 y in a prospective population-based cohort, the Southampton Women's Survey. METHODS: In 493 mother-offspring pairs, we assessed linear size using high-resolution ultrasound at 11, 19, and 34 wk gestation (femur length) and at birth and 1, 2, 3,4, and 6 y (crown-heel length/height). SD scores were created and conditional regression modeling generated mutually independent growth variables. Children underwent hip dual-energy X-ray absorptiometry (DXA) at 6 y; hip structure analysis software yielded measures of geometry and strength. RESULTS: There were strong associations between early linear growth and femoral neck section modulus (Z) at 6 y, with the strongest relationships observed for femur growth from 19 to 34 wk gestation (beta = 0.26 cm(3)/SD, P < 0.0001), and for height growth from birth to 1 y (beta = 0.25 cm(3)/SD, P < 0.0001) and 1 to 2 y (beta = 0.33 cm(3)/SD, P < 0.0001), with progressively weaker relationships over years 3 (beta = 0.23 cm(3)/SD, P = 0.0002) and 4 (beta = 0.10 cm(3)/SD, P = 0.18). CONCLUSION: These results demonstrate that growth before age 3 y predicts proximal femoral geometry at 6 y old. These data suggest critical periods in which there is capacity for long-term influence on the later skeletal growth trajectory.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据