期刊
TRENDS IN CELL BIOLOGY
卷 25, 期 2, 页码 65-73出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2014.10.002
关键词
centrosome disjunction; centrosome movement; centrosome dynamics; chromosomal instability; cancer
类别
资金
- National Institutes of Health [F30 CA189339-01, T32 GM 65841, CA126828]
Accurate segregation of duplicated chromosomes between two daughter cells depends on bipolar spindle formation, a. metaphase state in which sister kinetochores are attached to microtubules emanating from opposite spindle poles. To ensure bi-orientation, cells possess surveillance systems that safeguard against microtubule-kinetochore attachment defects, including the spindle assembly checkpoint and the error correction machinery. However, recent developments have identified centrosome dynamics - that is, centrosome disjunction and poleward movement of duplicated centrosomes - as a central target for deregulation of bi-orientation in cancer cells. In this review, we discuss novel insights into the mechanisms that underlie centrosome dynamics and discuss how these mechanisms are perturbed in cancer cells to drive chromosome mis-segregation and advance neoplastic transformation.
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