期刊
TRENDS IN CELL BIOLOGY
卷 25, 期 4, 页码 214-220出版社
CELL PRESS
DOI: 10.1016/j.tcb.2014.11.001
关键词
innate immune cells; inflammation; cancer development
类别
资金
- National Cancer Institute [R01 CA057621]
- Tegger Foundation
Cells of the innate immune system have a dual role in cancer development in both tumor initiation and progression. Innate immune cells can, on the one hand, aid malignant transformation and tumor outgrowth and, on the other hand, prevent tumor progression. The innate immune system has the ability to tune the inflammatory response and is a key player in cancer-related inflammation, which can precede the development of malignancy or be induced by oncogenic changes promoting a protumor inflammatory milieu. In this review, we discuss the emerging cellular and molecular mechanisms of the innate immune system and inflammation in tumor initiation and progression, and point to the outstanding questions that remain.
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