期刊
PEDIATRIC RESEARCH
卷 69, 期 5, 页码 34R-40R出版社
NATURE PUBLISHING GROUP
DOI: 10.1203/PDR.0b013e318212b80f
关键词
-
类别
资金
- National Institute of Mental Health [R01 MH079299, EUREKA MH086781, ARRA MH088879, P50 MH086383]
- Binational Science Foundation
- International Rett Syndrome Foundation
- Simons Foundation
- Autism Speaks Foundation
A variety of features of autism can be simulated in rodents, including the core behavioral hallmarks of stereotyped and repetitive behaviors, and deficits in social interaction and communication. Other behaviors frequently found in autism spectrum disorders (ASDs) such as neophobia, enhanced anxiety, abnormal pain sensitivity and eye blink conditioning, disturbed sleep patterns, seizures, and deficits in sensorimotor gating are also present in some of the animal models. Neuropathology and some characteristic neurochemical changes that are frequently seen in autism, and alterations in the immune status in the brain and periphery are also found in some of the models. Several known environmental risk factors for autism have been successfully established in rodents, including maternal infection and maternal valproate administration. Also under investigation are a number of mouse models based on genetic variants associated with autism or on syndromic disorders with autistic features. This review briefly summarizes recent developments in this field, highlighting models with face and/or construct validity, and noting the potential for investigation of pathogenesis, and early progress toward clinical testing of potential therapeutics. Wherever possible, reference is made to reviews rather than to primary articles. (Pediatr Res 69: 34R-40R, 2011)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据