期刊
PEDIATRIC RESEARCH
卷 67, 期 6, 页码 630-635出版社
NATURE PUBLISHING GROUP
DOI: 10.1203/PDR.0b013e3181dbbd18
关键词
-
类别
资金
- NICHD [12714]
- Women and Infants Research Foundation
- NHMRC
- Sylvia and Charles Viertel Senior Medical Research Fellowship
- NHLBI [K08HL097085]
- NHFA
Ureaplasma species are the microorganisms most frequently isolated from women with preterm birth and are associated with an increased risk of bronchopulmonary dysplasia. Initiation of ventilation with high tidal volumes (V-T) causes lung injury and inflammation. We investigated whether antenatal colonization with Ureaplasma parvum serovar 3 (UP) would alter the inflammatory response to mechanical ventilation of preterm lambs. Merino ewes were given intraamniotic injections of UP at 55-d gestation, and the lambs were surgically delivered at 128 +/- 1 d gestation and assigned to three groups: 1) gentle ventilation (GV), 2) high V-T ventilation, or 3) unventilated control. Lambs delivered from noncolonized ewes were assigned to parallel groups. GV lambs received surfactant before ventilation with a V-T of 7 mL/kg, positive end expiratory pressure (PEEP) 5 cm H2O High V-T lambs received no PEEP and escalating V-T to 15 mL/kg by 15 min. At 15 min, surfactant was given, V-T was reduced to 7 mL/kg, and PEEP was increased to 5 cm H2O. Monocytes in bronchoalveolar lavage were increased by UP, but colonization did not affect lung function. High V-T ventilation increased Egr-1 signaling, proinflammatory cytokine expression, and injury scores compared with GV. Antenatal colonization with UP did not change lung function or modulate the lung injury and inflammation caused by high V-T ventilation. (Pediatr Res 67: 630-635, 2010)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据