期刊
TRENDS IN BIOTECHNOLOGY
卷 33, 期 4, 页码 208-213出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2015.02.002
关键词
intestinal gas; gut microbiome; therapeutics; in vitro fermentation; gas capsule
资金
- Australian National Health and Medical Research Council (NHMRC) [1075568]
- Australian Government Department of Agriculture's Filling the Research Gap Program [B.CCH.6220]
- National Health and Medical Research Council of Australia [1075568] Funding Source: NHMRC
The biological and clinical significance of the human gut microbiome is currently attracting worldwide attention. While rRNA and DNA technologies led to a quantum leap in our understanding of the numbers and types of gut microorganisms, much less is known about these microorganisms' activity in situ and in real time. Accurately measuring their byproducts, including intestinal gases, may offer unique biomarkers for specific gut microbiota, accelerating our understanding of the relationships among intestinal gases, the metabolic activity of the gut microbiome, and human health states. Here we present two novel techniques, namely in vitro fermentation and gas capsule systems, for measuring and assessing selected gas species. We discuss new developments with these technologies and the methods of their implementation and provide an overall review of their operation.
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