期刊
TRENDS IN BIOTECHNOLOGY
卷 33, 期 5, 页码 302-314出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2015.02.010
关键词
biocatalytic process; microscale technology; process intensification; flow synthesis; miniaturized production; enzymatic microreactors
资金
- EU [KBBE 2012.3.3-03, 312148]
- EUROMBR - European Network for Innovative Microbioreactor Applications in Bioprocess Development [608104]
- Ministry of Education, Science, and Sport of the Republic of Slovenia [P2-0191]
Despite the expanding presence of microscale technology in chemical synthesis and energy production as well as in biomedical devices and analytical and diagnostic tools, its potential in biocatalytic processes for pharmaceutical and fine chemicals, as well as related industries, has not yet been fully exploited. The aim of this review is to shed light on the strategic advantages of this promising technology for the development and realization of biocatalytic processes and subsequent product recovery steps, demonstrated with examples from the literature. Constraints, opportunities, and the future outlook for the implementation of these key green engineering methods and the role of supporting tools such as mathematical models to establish sustainable production processes are discussed.
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