期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 40, 期 10, 页码 560-575出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2015.07.008
关键词
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资金
- EMBO long-term fellowship [ALTF644-2014]
- Communaute Francaise de Belgique ('Action de Recherches Concertees')
- Region Wallonne (DG06, CWALity)
- Fonds National de la Recherche Scientifique (FRS/FNRS)
- European Regional Development Fund (ERDF)
- Universite Libre de Bruxelles (ULB)
Eukaryotic rRNA are modified frequently, although the diversity of modifications is low: in yeast rRNA, there are only 12 different types out of a possible natural repertoire exceeding 112. All nine rRNA base methyltransferases (MTases) and one acetyltransferase have recently been identified in budding yeast, and several instances of crosstalk between rRNA, tRNA, and mRNA modifications are emerging. Although the machinery has largely been identified, the functions of most rRNA modifications remain to be established. Remarkably, a eukaryotespecific bridge, comprising a single ribosomal protein (RP) from the large subunit (LSU), contacts four rRNA base modifications across the ribosomal subunit interface, potentially probing for their presence. We hypothesize in this article that long-range allosteric communication involving rRNA modifications is taking place between the two subunits during translation or, perhaps, the late stages of ribosome assembly.
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