期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 40, 期 8, 页码 435-445出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2015.05.001
关键词
antioxidant enzyme; peroxidase; redox signaling; antioxidant defense
资金
- National Institutes of Health [R01 GM050389, R33 CA177461]
- NATIONAL CANCER INSTITUTE [R33CA177461] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM050389] Funding Source: NIH RePORTER
Peroxiredoxins (Prxs) are a ubiquitous family of cysteine-dependent peroxidase enzymes that play dominant roles in regulating peroxide levels within cells. These enzymes, often present at high levels and capable of rapidly clearing peroxides, display a remarkable array of variations in their oligomeric states and susceptibility to regulation by hyperoxidative inactivation and other post-translational modifications. Key conserved residues within the active site promote catalysis by stabilizing the transition state required for transferring the terminal oxygen of hydroperoxides to the active site (peroxidatic) cysteine residue. Extensive investigations continue to expand our understanding of the scope of their importance as well as the structures and forces at play within these critical defense and regulatory enzymes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据