期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 40, 期 2, 页码 67-71出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2014.10.012
关键词
DNA-protein crosslinks; DNA repair; DPC protease; DVC1; Spartan; SPRTN; Wss1
DNA protein crosslinks (DPCs) are highly toxic DNA lesions because they interfere with DNA transactions. The recent discovery of a yeast protease that processes DPCs proteolytically raises the question whether DPC proteases also exist in higher eukaryotes. We argue here that the yeast enzyme, Wss1 (weak suppressor of smt3), is a member of a protease family whose mammalian representative is Spartan (SprT-like domain-containing protein)/DVC1 (DNA damage protein targeting VCP). DPC proteases may thus be common to all eukaryotes where they function as novel guardians of the genome.
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