期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 40, 期 3, 页码 165-171出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2015.01.007
关键词
transcription; core promoter; RNA Pol II; noncoding RNAs
资金
- Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research
Early studies established that transcription initiates within an approximately 50 bp DNA segment capable of nucleating the assembly of RNA polymerase II (Pol II) and associated general transcription factors (GTFs) necessary for transcriptional initiation; this region is called a core promoter. Subsequent analyses identified a series of conserved DNA sequence elements, present in various combinations or not at all, in core promoters. Recent genome-wide analyses have provided further insights into the complexity of core promoter architecture and function. Here we review recent studies that delineate the active role of core promoters in the transcriptional regulation of diverse physiological systems.
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