期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 40, 期 3, 页码 127-129出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2015.01.005
关键词
basal transcription machinery; diversification; evolution; gene regulation; system factors; TATA-binding protein (TBP); TBP-related factor (TRF); transcription
资金
- NIGMS NIH HHS [R01 GM041249] Funding Source: Medline
Transcription initiation was once thought to be regulated primarily by sequence-specific transcription factors with the basal transcription machinery being largely invariant. Gradually it became apparent that the basal transcription machinery greatly diversified during evolution and new studies now demonstrate that diversification of the TATA-binding protein (TBP) family yielded specialized and largely independent transcription systems.
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